ea0081p189 | Reproductive and Developmental Endocrinology | ECE2022
Risal Sanjiv
, Li Congru
, Luo Qing
, Fornes Romina
, Manti Maria
, Lu Haojiang
, Eriksson Gustaw
, Ohlsson Claes
, Lindgren Eva
, Crisosto Nicolas
, Maliqueo Manuel
, Echiburu Barbara
, Recabarren Sergio
, Sir Petermann Teresa
, Benrick Anna
, Brusselaers Nele
, Qiao Jie
, Deng Qiaolin
, Stener-Victorin Elisabet
Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...